Skip to main content
eScholarship
Open Access Publications from the University of California

Sustainable ppm level palladium-catalyzed aminations in nanoreactors under mild, aqueous conditions.

  • Author(s): Zhang, Yitao
  • Takale, Balaram S
  • Gallou, Fabrice
  • Reilly, John
  • Lipshutz, Bruce H
  • et al.
Abstract

A 1 : 1 Pd : ligand complex, [t-BuXPhos(Pd-π-cinnamyl)]OTf, has been identified as a highly robust pre-catalyst for amination reactions leading to diarylamines, where loadings of metal are typically at 1000 ppm Pd, run in water at temperatures between rt and 45 °C. The protocol is exceptionally simple, is readily scaled, and compares very favorably vs. traditional amination conditions. It has also been shown to successfully lead to key intermediates associated with several physiologically active compounds.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View