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Open Access Publications from the University of California

High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μ m

  • Author(s): Piao, Z
  • Ma, T
  • Li, J
  • Wiedmann, MT
  • Huang, S
  • Yu, M
  • Kirk Shung, K
  • Zhou, Q
  • Kim, CS
  • Chen, Z
  • et al.

Published Web Location Commons Attribution 4.0 International Public License

© 2015 AIP Publishing LLC. Intravascular photoacoustic imaging at 1.7μm spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500Hz optical parametric oscillator laser at 1725nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.

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