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It Takes Two to Tango: Dual Inhibition of PI3K and MAPK in Rhabdomyosarcoma
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https://doi.org/10.1158/1078-0432.ccr-13-2177Abstract
The PI3K/AKT/mTOR and RAS/RAF/MAPK pathways play essential roles in rhabdomyosarcoma. Singular targeting of each pathway is ineffective due to extensive cross-talk and compensatory feedback between these two pathways. Dual blockade with inhibitors of PI3K and MAPK in combination synergistically inhibits growth of rhabdomyosarcoma both in vitro and in vivo.
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