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Open Access Publications from the University of California

Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy.

  • Author(s): Colomb, Florent
  • Giron, Leila B
  • Kuri-Cervantes, Leticia
  • Adeniji, Opeyemi S
  • Ma, Tongcui
  • Dweep, Harsh
  • Battivelli, Emilie
  • Verdin, Eric
  • Palmer, Clovis S
  • Tateno, Hiroaki
  • Kossenkov, Andrew V
  • Roan, Nadia R
  • Betts, Michael R
  • Abdel-Mohsen, Mohamed
  • et al.

A comprehensive understanding of the phenotype of persistent HIV-infected cells, transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure. The relevance of cell-surface glycosylation to HIV persistence has never been explored. We characterize the relationship between cell-surface glycomic signatures and persistent HIV transcription in vivo. We find that the cell surface of CD4+ T cells actively transcribing HIV, despite suppressive therapy, harbors high levels of fucosylated carbohydrate ligands, including the cell extravasation mediator Sialyl-LewisX (SLeX), compared with HIV-infected transcriptionally inactive cells. These high levels of SLeX are induced by HIV transcription in vitro and are maintained after therapy in vivo. Cells with high-SLeX are enriched with markers associated with HIV susceptibility, signaling pathways that drive HIV transcription, and pathways involved in leukocyte extravasation. We describe a glycomic feature of HIV-infected transcriptionally active cells that not only differentiates them from their transcriptionally inactive counterparts but also may affect their trafficking abilities.

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