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Reconfiguration of the proteasome during chaperone-mediated assembly
- Park, Soyeon;
- Li, Xueming;
- Kim, Ho Min;
- Singh, Chingakham Ranjit;
- Tian, Geng;
- Hoyt, Martin A;
- Lovell, Scott;
- Battaile, Kevin P;
- Zolkiewski, Michal;
- Coffino, Philip;
- Roelofs, Jeroen;
- Cheng, Yifan;
- Finley, Daniel
Published Web Location
https://doi.org/10.1038/nature12123Abstract
The proteasome degrades ubiquitin-conjugated substrates; here, structural and functional insights from studies in yeast reveal that it is reconfigured during chaperone-mediated assembly.
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