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Open Access Publications from the University of California

Platymonas subcordiformis channelrhodopsin-2 (PsChR2) function II. Relationship of the photochemical reaction cycle to channel currents

  • Author(s): Szundi, I
  • Bogomolni, R
  • Kliger, DS
  • et al.

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Channelrhodopsins (ChRs) are light-gated cation channels widely used in optogenetics. Results: The photocycle obtained from time-resolved absorption spectroscopy of PsChR2 is shown to explain photocurrent kinetics observed in HEK293 cells. Conclusion: The photochemical reactions involving two parallel photocycles result in the complex photocurrent behavior. Significance: The parallel-cycle model opens new perspectives in understanding photocurrents from channelrhodopsins.

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