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The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
- Onizawa, Michio;
- Oshima, Shigeru;
- Schulze-Topphoff, Ulf;
- Oses-Prieto, Juan A;
- Lu, Timothy;
- Tavares, Rita;
- Prodhomme, Thomas;
- Duong, Bao;
- Whang, Michael I;
- Advincula, Rommel;
- Agelidis, Alex;
- Barrera, Julio;
- Wu, Hao;
- Burlingame, Alma;
- Malynn, Barbara A;
- Zamvil, Scott S;
- Ma, Averil
Published Web Location
https://doi.org/10.1038/ni.3172Abstract
A20 is a deubiquitinating enzyme that restrict inflammation by various mechanisms. Ma and colleagues show that A20 inhibits necroptosis by inhibiting the ubiquitination of RIPK3 and formation of the RIPK1-RIPK3 complex.
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