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Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation
- Lin, Kimberly C;
- Moroishi, Toshiro;
- Meng, Zhipeng;
- Jeong, Han-Sol;
- Plouffe, Steven W;
- Sekido, Yoshitaka;
- Han, Jiahuai;
- Park, Hyun Woo;
- Guan, Kun-Liang
Published Web Location
https://doi.org/10.1038/ncb3581Abstract
Lin et al. find that stress-induced p38 MAPK activation leads to cytoplasmic relocation of the Hippo pathway nuclear transcription factor TEAD. TEAD relocation causes inhibition of YAP activity and suppresses YAP-driven cancer cell growth.
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