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A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
- Dodd, Dylan;
- Spitzer, Matthew H;
- Van Treuren, William;
- Merrill, Bryan D;
- Hryckowian, Andrew J;
- Higginbottom, Steven K;
- Le, Anthony;
- Cowan, Tina M;
- Nolan, Garry P;
- Fischbach, Michael A;
- Sonnenburg, Justin L
Published Web Location
https://doi.org/10.1038/nature24661Abstract
A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity.
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