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Infection and the Perils of B-cell Activation
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https://doi.org/10.1158/2159-8290.cd-15-1243Abstract
Recent studies have linked aberrant B-cell activation in the context of aberrant immune responses to infectious pathogens to malignant transformation and development of leukemia and lymphoma. A new study in this issue demonstrates that common infections can be drivers of clonal evolution of premalignant B-cell precursors toward childhood leukemia.
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