Skip to main content
eScholarship
Open Access Publications from the University of California

Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.

  • Author(s): Ryu, Keun Ah
  • McGonnigal, Bethany
  • Moore, Troy
  • Kargupta, Tawnya
  • Mancini, Rock J
  • Esser-Kahn, Aaron P
  • et al.
Abstract

The complexity of the immune system creates challenges in exploring its importance and robustness. To date, there have been few techniques developed to manipulate individual components of the immune system in an in vivo environment. Here we show a light-based dendritic cell (DC) activation allowing spatial and temporal control of immune activation in vivo. Additionally, we show time dependent changes in RNA profiles of the draining lymph node, suggesting a change in cell profile following DC migration and indicating that the cells migrating have been activated towards antigen presentation.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View