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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- Shi, Yang;
- Yamada, Kaoru;
- Liddelow, Shane Antony;
- Smith, Scott T;
- Zhao, Lingzhi;
- Luo, Wenjie;
- Tsai, Richard M;
- Spina, Salvatore;
- Grinberg, Lea T;
- Rojas, Julio C;
- Gallardo, Gilbert;
- Wang, Kairuo;
- Roh, Joseph;
- Robinson, Grace;
- Finn, Mary Beth;
- Jiang, Hong;
- Sullivan, Patrick M;
- Baufeld, Caroline;
- Wood, Michael W;
- Sutphen, Courtney;
- McCue, Lena;
- Xiong, Chengjie;
- Del-Aguila, Jorge L;
- Morris, John C;
- Cruchaga, Carlos;
- Fagan, Anne M;
- Miller, Bruce L;
- Boxer, Adam L;
- Seeley, William W;
- Butovsky, Oleg;
- Barres, Ben A;
- Paul, Steven M;
- Holtzman, David M
Published Web Location
https://doi.org/10.1038/nature24016Abstract
ApoE4 exacerbates tau pathogenesis, neuroinflammation and tau-mediated neurodegeneration independently of brain amyloid-β pathology, and exerts a ‘toxic’ gain of function whereas its absence is protective.
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