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Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57
- Tjiam, M Christian;
- Morshidi, Mazmah A;
- Sariputra, Lucy;
- Martin, Jeffrey N;
- Deeks, Steven G;
- Tan, Dino BA;
- Lee, Silvia;
- Fernandez, Sonia;
- French, Martyn A
Published Web Location
https://doi.org/10.1097/qai.0000000000001477Abstract
To expand upon our previous observation that HIV-1 Gag-specific IgG antibodies were highest in HIV controllers not carrying HLA-B*57:01, we analysed these antibodies in a larger cohort of viremic controllers (VCs) or elite controllers (ECs) considering carriage of ‘protective’ HLA-B alleles. HIV-1 p24-specific IgG1 and IgG2 antibodies were higher only in HLA-B*57:01− VCs but there were no differences in ECs. Associations of HIV-1 gp140-specific IgG antibodies with HLA-B*57:01 carriage were inconsistent amongst VCs and ECs.
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