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Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
- Liu, Jian;
- Divoux, Adeline;
- Sun, Jiusong;
- Zhang, Jie;
- Clément, Karine;
- Glickman, Jonathan N;
- Sukhova, Galina K;
- Wolters, Paul J;
- Du, Juan;
- Gorgun, Cem Z;
- Doria, Alessandro;
- Libby, Peter;
- Blumberg, Richard S;
- Kahn, Barbara B;
- Hotamisligil, Gökhan S;
- Shi, Guo-Ping
Published Web Location
https://doi.org/10.1038/nm.1994Abstract
Mast cells, which are involved in inflammation and wound healing, have now been shown to have a role in obesity and diabetes in a new report by Guo-Ping Shi and his colleagues. They go on to show that pharmacological inhibition of mast cell function is sufficient to reduce these metabolic disturbances in mice, suggesting a new therapeutic avenue in the clinic for these disorders.
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