Development of a Multigram synthesis of URB937, a peripherally restricted FAAH inhibitor
- Author(s): Fiorelli, C
- Scarpelli, R
- Piomelli, D
- Bandiera, T
- et al.
Published Web Locationhttps://doi.org/10.1021/op300301u
A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield. © 2013 American Chemical Society.