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Development of a Multigram Synthesis of URB937, a Peripherally Restricted FAAH Inhibitor

Published Web Location Commons 'BY' version 4.0 license

A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield. © 2013 American Chemical Society.

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