Development of a Multigram Synthesis of URB937, a Peripherally Restricted FAAH Inhibitor
Published Web Locationhttps://doi.org/10.1021/op300301u
A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield. © 2013 American Chemical Society.