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Development of a Multigram synthesis of URB937, a peripherally restricted FAAH inhibitor

  • Author(s): Fiorelli, C;
  • Scarpelli, R;
  • Piomelli, D;
  • Bandiera, T
  • et al.

Published Web Location

https://doi.org/10.1021/op300301uCreative Commons 'BY' version 4.0 license
Abstract

A new synthetic approach to URB937 was developed starting from the inexpensive and widely available 4-benzyloxyphenol. A reproducible four-step procedure, requiring no chromatographic purifications, was optimized that allowed the preparation of 100 g of URB937 in 45% overall yield. © 2013 American Chemical Society.

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