Kang, Ju‐Hee; Korecka, Magdalena; Figurski, Michal J; Toledo, Jon B; Blennow, Kaj; Zetterberg, Henrik; Waligorska, Teresa; Brylska, Magdalena; Fields, Leona; Shah, Nirali; Soares, Holly; Dean, Robert A; Vanderstichele, Hugo; Petersen, Ronald C; Aisen, Paul S; Saykin, Andrew J; Weiner, Michael W; Trojanowski, John Q; Shaw, Leslie M; Initiative, Alzheimer's Disease Neuroimaging

doi:10.1016/j.jalz.2015.05.003

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The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans

Published Web Location

https://doi.org/10.1016/j.jalz.2015.05.003

Abstract

Introduction

We describe Alzheimer's Disease Neuroimaging Initiative (ADNI) Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ1-42), t-tau, and p-tau181 analytical performance, definition of Alzheimer's disease (AD) profile for plaque, and tangle burden detection and increased risk for progression to AD; AD disease heterogeneity; progress in standardization; and new studies using ADNI biofluids.

Methods

Review publications authored or coauthored by ADNI Biomarker core faculty and selected non-ADNI studies to deepen the understanding and interpretation of CSF Aβ1-42, t-tau, and p-tau181 data.

Results

CSF AD biomarker measurements with the qualified AlzBio3 immunoassay detects neuropathologic AD hallmarks in preclinical and prodromal disease stages, based on CSF studies in non-ADNI living subjects followed by the autopsy confirmation of AD. Collaboration across ADNI cores generated the temporal ordering model of AD biomarkers varying across individuals because of genetic/environmental factors that increase/decrease resilience to AD pathologies.

Discussion

Further studies will refine this model and enable the use of biomarkers studied in ADNI clinically and in disease-modifying therapeutic trials.

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