Skip to main content
eScholarship
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Investigation of laser-induced cell lysis using time-resolved imaging

  • Author(s): Rau, KR
  • Guerra, A
  • Vogel, A
  • Venugopalan, V
  • et al.

Published Web Location

https://doi.org/10.1063/1.1705728Creative Commons 'BY' version 4.0 license
Abstract

The lysis of confluent PtK2 cell cultures was investigated by pulsed laser microbeam irradiation. Lysis to be mediated by laser-induced plasma formation was demonstrated by images obtained at time delays of 0.5 ns to 50 μs. The quantitative characterization of the pressure wave and cavitation bubble dynamics were enabled by image analysis. The results show that the zone of cell damage exceeded the plasma size and serves to implicate cavitation bubble expansions as the primary agent of cell injury.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View