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Progranulin, lysosomal regulation and neurodegenerative disease
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https://doi.org/10.1038/nrn.2017.36Abstract
Recent studies suggest that progranulin has an important role in lysosome biogenesis and innate immunity in the brain. In this Progress article, Kao and colleagues suggest that progranulin also plays a part in suppressing excessive neuroinflammation during ageing.
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