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Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake
- Seif, Taban;
- Chang, Shao-Ju;
- Simms, Jeffrey A;
- Gibb, Stuart L;
- Dadgar, Jahan;
- Chen, Billy T;
- Harvey, Brandon K;
- Ron, Dorit;
- Messing, Robert O;
- Bonci, Antonello;
- Hopf, F Woodward
Published Web Location
https://doi.org/10.1038/nn.3445Abstract
The authors show that optogenetic inhibition of inputs from medial prefrontal cortex (mPFC) or insula to the nucleus accumbens core (NAcore) inhibits aversion-resistant alcohol intake. Alcohol-drinking rats showed increased hyperpolarization-active NMDARs at mPFC and insula inputs to NAcore medium spiny neurons. Knocking down these receptors in the NAcore inhibited aversion-resistant alcohol intake.
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