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Mechanism in Protein Chemistry, 2nd edition

The data associated with this publication are in the supplemental files.
Abstract

It is the purpose of this book to present a comprehensive description of the strategies that are used by enzymes to catalyze their respective reactions rather than a comprehensive, encyclopedic catalogue of the enzymes for which mechanisms are available. It does not systematically present the mechanisms of each enzyme in its appropriate category. It is also the purpose of this book to describe the many techniques that are used to study enzymatic mechanisms. Each method provides information about a particular strategy and can be discussed as the respective strategy is discussed. The most informative observation about the mechanism of an enzyme is a crystallographic molecular model of that enzyme with its active site occupied by substrates in equilibrium with each other in which reactants and products are both observed or by an analogue of a high-energy intermediate in the normal reaction, but the majority of our understanding of the mechanisms of enzymatic reactions comes from chemical studies of these mechanisms.

This is the second edition of a previously published volume Mechanism in Protein Chemistry. This second edition has been completely rewritten and brought up to date by a comprehensive review of the biochemical literature for the thirty years since the publication of the first edition. Many of the earlier figures have been discarded and most of the figures in this second edition are new, describing experimental results that have been reported in the last thiry years. This edition will not be published as a book and will only be available in this electronic version.

The file containing the text of the book is accompanied by supplemental material that contains all of the Equations, Structures, Figures, and Tables in the order in which they appear in the text. This list is intended to make it easier for the reader to find one of these items when it is mentioned in the text.

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