Clinical Practice and Cases in Emergency Medicine

Cyproheptadine is an H-1 antihistamine with anticholinergic and antiserotonergic effects.Cyproheptadine’s most common use has been in the management cold-induced urticaria. It is often usedin primary care for its side effect of appetite stimulation. Recently there has been increasing interest inits use in the treatment of drug-induced serotonin syndrome. Cyproheptadine overdose is uncommonlyreported in the medical literature. We report the rare case of a pediatric cyproheptadine overdose with aconfirmatory cyproheptadine level.