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Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial.

  • Author(s): Daubenmier, Jennifer;
  • Moran, Patricia J;
  • Kristeller, Jean;
  • Acree, Michael;
  • Bacchetti, Peter;
  • Kemeny, Margaret E;
  • Dallman, Mary;
  • Lustig, Robert H;
  • Grunfeld, Carl;
  • Nixon, Douglas F;
  • Milush, Jeffrey M;
  • Goldman, Veronica;
  • Laraia, Barbara;
  • Laugero, Kevin D;
  • Woodhouse, Leslie;
  • Epel, Elissa S;
  • Hecht, Frederick M
  • et al.

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To determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components.


In this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change.


Estimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P = 0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; P = 0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, -3.1 mg/dl (95% CI: -6.3, 0.1; P = 0.06), and 18 months, -4.1 mg/dl (95% CI: -7.3, -0.9; P = 0.01); and (c) changes in triglyceride/HDL ratio at 12 months, -0.57 (95% CI: -0.95, -0.18; P = 0.004), and 18 months, -0.36 (95% CI: -0.74, 0.03; P = 0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein.


Mindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.

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