Skip to main content
Download PDF
- Main
Mitochondria Cripple without Krüppel
Published Web Location
https://doi.org/10.1016/j.tem.2015.08.004Abstract
Proper mitochondrial biogenesis and removal is crucial in maintaining a healthy heart. Liao et al now show key roles for cardiac KLF4 in mitochondrial homeostasis via its interaction with the ERR/PGC-1 module, and mitochondrial clearance via regulation of mitophagy. Disruption of KLF4 leads to profoundly injured mitochondria and cardiac failure.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.