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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
- Youm, Yun-Hee;
- Nguyen, Kim Y;
- Grant, Ryan W;
- Goldberg, Emily L;
- Bodogai, Monica;
- Kim, Dongin;
- D'Agostino, Dominic;
- Planavsky, Noah;
- Lupfer, Christopher;
- Kanneganti, Thirumala D;
- Kang, Seokwon;
- Horvath, Tamas L;
- Fahmy, Tarek M;
- Crawford, Peter A;
- Biragyn, Arya;
- Alnemri, Emad;
- Dixit, Vishwa Deep
Published Web Location
https://doi.org/10.1038/nm.3804Abstract
Ketone bodies are elevated in response to fasting, a low-carbohydrate ketogenic diet or high-intensity exercise. Vishwa Deep Dixit and colleagues report that one metabolite, β-hydroxybutyrate, inhibits the NLRP3 inflammasome. In vivo, β-hydroxybutyrate is anti-inflammatory and suppresses NLRP3-mediated inflammatory disease.
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