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Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma
- Huang, Phillips Y;
- Kandyba, Eve;
- Jabouille, Arnaud;
- Sjolund, Jonas;
- Kumar, Atul;
- Halliwill, Kyle;
- McCreery, Melissa;
- DelRosario, Reyno;
- Kang, Hio Chung;
- Wong, Christine E;
- Seibler, Jost;
- Beuger, Vincent;
- Pellegrino, Maurizio;
- Sciambi, Adam;
- Eastburn, Dennis J;
- Balmain, Allan
Published Web Location
https://doi.org/10.1038/ng.3957Abstract
Lineage-tracing experiments in the mouse show that Lgr6, but not Lgr5, functions as a cancer stem marker in skin squamous cell carcinomas (SCCs). The authors also show that Lgr6-knockout mice are predisposed to SCC development, through a mechanism that includes compensatory upregulation of Lgr5.
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