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Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
- Day, Felix R;
- Thompson, Deborah J;
- Helgason, Hannes;
- Chasman, Daniel I;
- Finucane, Hilary;
- Sulem, Patrick;
- Ruth, Katherine S;
- Whalen, Sean;
- Sarkar, Abhishek K;
- Albrecht, Eva;
- Altmaier, Elisabeth;
- Amini, Marzyeh;
- Barbieri, Caterina M;
- Boutin, Thibaud;
- Campbell, Archie;
- Demerath, Ellen;
- Giri, Ayush;
- He, Chunyan;
- Hottenga, Jouke J;
- Karlsson, Robert;
- Kolcic, Ivana;
- Loh, Po-Ru;
- Lunetta, Kathryn L;
- Mangino, Massimo;
- Marco, Brumat;
- McMahon, George;
- Medland, Sarah E;
- Nolte, Ilja M;
- Noordam, Raymond;
- Nutile, Teresa;
- Paternoster, Lavinia;
- Perjakova, Natalia;
- Porcu, Eleonora;
- Rose, Lynda M;
- Schraut, Katharina E;
- Segrè, Ayellet V;
- Smith, Albert V;
- Stolk, Lisette;
- Teumer, Alexander;
- Andrulis, Irene L;
- Bandinelli, Stefania;
- Beckmann, Matthias W;
- Benitez, Javier;
- Bergmann, Sven;
- Bochud, Murielle;
- Boerwinkle, Eric;
- Bojesen, Stig E;
- Bolla, Manjeet K;
- Brand, Judith S;
- Brauch, Hiltrud;
- Brenner, Hermann;
- Broer, Linda;
- Brüning, Thomas;
- Buring, Julie E;
- Campbell, Harry;
- Catamo, Eulalia;
- Chanock, Stephen;
- Chenevix-Trench, Georgia;
- Corre, Tanguy;
- Couch, Fergus J;
- Cousminer, Diana L;
- Cox, Angela;
- Crisponi, Laura;
- Czene, Kamila;
- Davey Smith, George;
- de Geus, Eco JCN;
- de Mutsert, Renée;
- De Vivo, Immaculata;
- Dennis, Joe;
- Devilee, Peter;
- dos-Santos-Silva, Isabel;
- Dunning, Alison M;
- Eriksson, Johan G;
- Fasching, Peter A;
- Fernández-Rhodes, Lindsay;
- Ferrucci, Luigi;
- Flesch-Janys, Dieter;
- Franke, Lude;
- Gabrielson, Marike;
- Gandin, Ilaria;
- Giles, Graham G;
- Grallert, Harald;
- Gudbjartsson, Daniel F;
- Guénel, Pascal;
- Hall, Per;
- Hallberg, Emily;
- Hamann, Ute;
- Harris, Tamara B;
- Hartman, Catharina A;
- Heiss, Gerardo;
- Hooning, Maartje J;
- Hopper, John L;
- Hu, Frank;
- Hunter, David J;
- Ikram, M Arfan;
- Im, Hae Kyung;
- Järvelin, Marjo-Riitta;
- Joshi, Peter K;
- Karasik, David;
- Kellis, Manolis;
- Kutalik, Zoltan;
- LaChance, Genevieve;
- Lambrechts, Diether;
- Langenberg, Claudia;
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- Laven, Joop SE;
- Lenarduzzi, Stefania;
- Li, Jingmei;
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- Lindstrom, Sara;
- Liu, YongMei;
- Luan, Jian'an;
- Mägi, Reedik;
- Mannermaa, Arto;
- Mbarek, Hamdi;
- McCarthy, Mark I;
- Meisinger, Christa;
- Meitinger, Thomas;
- Menni, Cristina;
- Metspalu, Andres;
- Michailidou, Kyriaki;
- Milani, Lili;
- Milne, Roger L;
- Montgomery, Grant W;
- Mulligan, Anna M;
- Nalls, Mike A;
- Navarro, Pau;
- Nevanlinna, Heli;
- Nyholt, Dale R;
- Oldehinkel, Albertine J;
- O'Mara, Tracy A;
- Padmanabhan, Sandosh;
- Palotie, Aarno;
- Pedersen, Nancy;
- Peters, Annette;
- Peto, Julian;
- Pharoah, Paul DP;
- Pouta, Anneli;
- Radice, Paolo;
- Rahman, Iffat;
- Ring, Susan M;
- Robino, Antonietta;
- Rosendaal, Frits R;
- Rudan, Igor;
- Rueedi, Rico;
- Ruggiero, Daniela;
- Sala, Cinzia F;
- Schmidt, Marjanka K;
- Scott, Robert A;
- Shah, Mitul;
- Sorice, Rossella;
- Southey, Melissa C;
- Sovio, Ulla;
- Stampfer, Meir;
- Steri, Maristella;
- Strauch, Konstantin;
- Tanaka, Toshiko;
- Tikkanen, Emmi;
- Timpson, Nicholas J;
- Traglia, Michela;
- Truong, Thérèse;
- Tyrer, Jonathan P;
- Uitterlinden, André G;
- Edwards, Digna R Velez;
- Vitart, Veronique;
- Völker, Uwe;
- Vollenweider, Peter;
- Wang, Qin;
- Widen, Elisabeth;
- van Dijk, Ko Willems;
- Willemsen, Gonneke;
- Winqvist, Robert;
- Wolffenbuttel, Bruce HR;
- Zhao, Jing Hua;
- Zoledziewska, Magdalena;
- Zygmunt, Marek;
- Alizadeh, Behrooz Z;
- Boomsma, Dorret I;
- Ciullo, Marina;
- Cucca, Francesco;
- Esko, Tõnu;
- Franceschini, Nora;
- Gieger, Christian;
- Gudnason, Vilmundur;
- Hayward, Caroline;
- Kraft, Peter;
- Lawlor, Debbie A;
- Magnusson, Patrik KE;
- Martin, Nicholas G;
- Mook-Kanamori, Dennis O;
- Nohr, Ellen A;
- Polasek, Ozren;
- Porteous, David;
- Price, Alkes L;
- Ridker, Paul M;
- Snieder, Harold;
- Spector, Tim D;
- Stöckl, Doris;
- Toniolo, Daniela;
- Ulivi, Sheila;
- Visser, Jenny A;
- Völzke, Henry;
- Wareham, Nicholas J;
- Wilson, James F;
- Spurdle, Amanda B;
- Thorsteindottir, Unnur;
- Pollard, Katherine S;
- Easton, Douglas F;
- Tung, Joyce Y;
- Chang-Claude, Jenny;
- Hinds, David;
- Murray, Anna;
- Murabito, Joanne M;
- Stefansson, Kari;
- Ong, Ken K;
- Perry, John RB
Published Web Location
https://doi.org/10.1038/ng.3841Abstract
John Perry, Ken Ong and colleagues analyze genotype data on ∼370,000 women and identify 389 independent signals that associate with age at menarche, implicating ∼250 genes. Their analyses suggest causal inverse associations, independent of BMI, between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men.
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