Skip to main content
eScholarship
Open Access Publications from the University of California

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

  • Author(s): Day, FR
  • Thompson, DJ
  • Helgason, H
  • Chasman, DI
  • Finucane, H
  • Sulem, P
  • Ruth, KS
  • Whalen, S
  • Sarkar, AK
  • Albrecht, E
  • Altmaier, E
  • Amini, M
  • Barbieri, CM
  • Boutin, T
  • Campbell, A
  • Demerath, E
  • Giri, A
  • He, C
  • Hottenga, JJ
  • Karlsson, R
  • Kolcic, I
  • Loh, P-R
  • Lunetta, KL
  • Mangino, M
  • Marco, B
  • McMahon, G
  • Medland, SE
  • Nolte, IM
  • Noordam, R
  • Nutile, T
  • Paternoster, L
  • Perjakova, N
  • Porcu, E
  • Rose, LM
  • Schraut, KE
  • Segre, AV
  • Smith, AV
  • Stolk, L
  • Teumer, A
  • Andrulis, IL
  • Bandinelli, S
  • Beckmann, MW
  • Benitez, J
  • Bergmann, S
  • Bochud, M
  • Boerwinkle, E
  • Bojesen, SE
  • Bolla, MK
  • Brand, JS
  • Brauch, H
  • Brenner, H
  • Broer, L
  • Bruning, T
  • Buring, JE
  • Campbell, H
  • Catamo, E
  • Chanock, S
  • Chenevix-Trench, G
  • Corre, T
  • Couch, FJ
  • Cousminer, DL
  • Cox, A
  • Crisponi, L
  • Czene, K
  • Smith, GD
  • de Geus, EJCN
  • de Mutsert, R
  • De Vivo, I
  • Dennis, J
  • Devilee, P
  • dos-Santos-Silva, I
  • Dunning, AM
  • Eriksson, JG
  • Fasching, PA
  • Fernandez-Rhodes, L
  • Ferrucci, L
  • Flesch-Janys, D
  • Franke, L
  • Gabrielson, M
  • Gandin, I
  • Giles, GG
  • Grallert, H
  • Gudbjartsson, DF
  • Guenel, P
  • Hall, P
  • Hallberg, E
  • Hamann, U
  • Harris, TB
  • Hartman, CA
  • Heiss, G
  • Hooning, MJ
  • Hopper, JL
  • Hu, F
  • Hunter, DJ
  • Ikram, MA
  • Im, HK
  • Jarvelin, M-R
  • Joshi, PK
  • Karasik, D
  • Kellis, M
  • Kutalik, Z
  • LaChance, G
  • Lambrechts, D
  • Langenberg, C
  • Launer, LJ
  • Laven, JSE
  • Lenarduzzi, S
  • Li, J
  • Lind, PA
  • Lindstrom, S
  • Liu, Y
  • Luan, J
  • Magi, R
  • Mannermaa, A
  • Mbarek, H
  • McCarthy, MI
  • Meisinger, C
  • Meitinger, T
  • Menni, C
  • Metspalu, A
  • Michailidou, K
  • Milani, L
  • Milne, RL
  • Montgomery, GW
  • Mulligan, AM
  • Nalls, MA
  • Navarro, P
  • Nevanlinna, H
  • Nyholt, DR
  • Oldehinkel, AJ
  • O'Mara, TA
  • Padmanabhan, S
  • Palotie, A
  • Pedersen, N
  • Peters, A
  • Peto, J
  • Pharoah, PDP
  • Pouta, A
  • Radice, P
  • Rahman, I
  • Ring, SM
  • Robino, A
  • Rosendaal, FR
  • Rudan, I
  • Rueedi, R
  • Ruggiero, D
  • Sala, CF
  • Schmidt, MK
  • Scott, RA
  • Shah, M
  • Sorice, R
  • Southey, MC
  • Sovio, U
  • Stampfer, M
  • Steri, M
  • Strauch, K
  • Tanaka, T
  • Tikkanen, E
  • Timpson, NJ
  • Traglia, M
  • Truong, T
  • Tyrer, JP
  • Uitterlinden, AG
  • Edwards, DRV
  • Vitart, V
  • Voelker, U
  • Vollenweider, P
  • Wang, Q
  • Widen, E
  • van Dijk, KW
  • Willemsen, G
  • Winqvist, R
  • Wolffenbuttel, BHR
  • Zhao, JH
  • Zoledziewska, M
  • Zygmunt, M
  • Alizadeh, BZ
  • Boomsma, DI
  • Ciullo, M
  • Cucca, F
  • Esko, T
  • Franceschini, N
  • Gieger, C
  • Gudnason, V
  • Hayward, C
  • Kraft, P
  • Lawlor, DA
  • Magnusson, PKE
  • Martin, NG
  • Mook-Kanamori, DO
  • Nohr, EA
  • Polasek, O
  • Porteous, D
  • Price, AL
  • Ridker, PM
  • Snieder, H
  • Spector, TD
  • Stoeckl, D
  • Toniolo, D
  • Ulivi, S
  • Visser, JA
  • Voelzke, H
  • Wareham, NJ
  • Wilson, JF
  • Spurdle, AB
  • Thorsteindottir, U
  • Pollard, KS
  • Easton, DF
  • Tung, JY
  • Chang-Claude, J
  • Hinds, D
  • Murray, A
  • Murabito, JM
  • Stefansson, K
  • Ong, KK
  • Perry, JRB
  • Study, LC
  • Consortium, I
  • Investigators, KAOCS
  • Consortium, ECA
  • Consortium, OCA
  • Consortium, P
  • et al.

Published Web Location

https://doi.org/10.1038/ng.3841
Abstract

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10-8) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain ∼7.4% of the population variance in age at menarche, corresponding to ∼25% of the estimated heritability. We implicate ∼250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues. Rare variants near the imprinted genes MKRN3 and DLK1 were identified, exhibiting large effects when paternally inherited. Mendelian randomization analyses suggest causal inverse associations, independent of body mass index (BMI), between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men. In aggregate, our findings highlight the complexity of the genetic regulation of puberty timing and support causal links with cancer susceptibility.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View