Direct synthesis of anilines and nitrosobenzenes from phenols.
- Author(s): St Amant, AH
- Frazier, CP
- Newmeyer, B
- Fruehauf, KR
- Read de Alaniz, J
- et al.
Published Web Locationhttps://doi.org/10.1039/c6ob00073h
A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution ((i)SOAr) process. The products are obtained in good yields under mild and metal-free conditions. The leaving group effect on reactions that proceed through mixed quionone monoketals has also been investigated and a predictive model has been established.