Skip to main content
eScholarship
Open Access Publications from the University of California

UC Santa Barbara

UC Santa Barbara Previously Published Works bannerUC Santa Barbara

Microglial microRNAs mediate sex-specific responses to tau pathology.

  • Author(s): Kodama, Lay
  • Guzman, Elmer
  • Etchegaray, Jon I
  • Li, Yaqiao
  • Sayed, Faten A
  • Zhou, Lu
  • Zhou, Yungui
  • Zhan, Lihong
  • Le, David
  • Udeochu, Joe C
  • Clelland, Claire D
  • Cheng, Zuolin
  • Yu, Guoqiang
  • Li, Qingyun
  • Kosik, Kenneth S
  • Gan, Li
  • et al.
Abstract

Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View