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Microglial microRNAs mediate sex-specific responses to tau pathology.

  • Author(s): Kodama, Lay
  • Guzman, Elmer
  • Etchegaray, Jon I
  • Li, Yaqiao
  • Sayed, Faten A
  • Zhou, Lu
  • Zhou, Yungui
  • Zhan, Lihong
  • Le, David
  • Udeochu, Joe C
  • Clelland, Claire D
  • Cheng, Zuolin
  • Yu, Guoqiang
  • Li, Qingyun
  • Kosik, Kenneth S
  • Gan, Li
  • et al.

Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.

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