Skip to main content
eScholarship
Open Access Publications from the University of California

Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues

  • Author(s): Hayakawa, CK
  • Spanier, J
  • Bevilacqua, F
  • Dunn, AK
  • You, JS
  • Tromberg, BJ
  • Venugopalan, V
  • et al.
Abstract

We introduce a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. We then feed this derivative information to a nonlinear optimization algorithm to determine the optical properties of the tissue heterogeneity under examination. We demonstrate the use of this approach to solve rapidly a two-region inverse problem of photon migration in the transport regime, for which diffusion-approximation-based approaches are not applicable. © 2001 Optical Society of America.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View