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The Relation of Plasmacytoid Dendritic Cells (pDCs) and Regulatory T-Cells (Tregs) with HPV Persistence in HIV-Infected and HIV-Uninfected Women
- Strickler, Howard D;
- Martinson, Jeffrey;
- Desai, Seema;
- Xie, Xianhong;
- Burk, Robert D;
- Anastos, Kathryn;
- Massad, L Stewart;
- Minkoff, Howard;
- Xue, Xiaonan;
- D'Souza, Gypsyamber;
- Levine, Alexandra M;
- Colie, Christine;
- Watts, D Heather;
- Palefsky, Joel M;
- Landay, Alan
Published Web Location
https://doi.org/10.1089/vim.2013.0097Abstract
Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.
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