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Parasite-induced T H 1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells
- Defranco, Anthony;
- Raetz, M;
- Hwang, SH;
- Wilhelm, CL;
- Kirkland, D;
- Benson, A;
- Sturge, CR;
- Mirpuri, J;
- Vaishnava, S;
- Hou, B;
- Defranco, AL
Published Web Location
http://europepmc.org/articles/PMC3552073?pdf=renderNo data is associated with this publication.
Abstract
Activation of Toll-like receptors (TLRs) by pathogens triggers cytokine production and T cell activation, immune defense mechanisms that are linked to immunopathology. Here we show that IFN-γ production by CD4 + T H 1 cells during mucosal responses to the
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