Low Post-treatment Recurrence After a Shortened All-Oral Regimen for Pulmonary Rifampicin- or Multidrug-Resistant Tuberculosis in Individuals Without Prior Second-Line Drug Exposure in Kazakhstan
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Low Post-treatment Recurrence After a Shortened All-Oral Regimen for Pulmonary Rifampicin- or Multidrug-Resistant Tuberculosis in Individuals Without Prior Second-Line Drug Exposure in Kazakhstan

et al.

Published Web Location

https://doi.org/10.1093/cid/ciag391
Creative Commons 'BY-NC' version 4.0 license
Abstract

Abstract: We conducted a prospective cohort study of adults with pulmonary multidrug or rifampicin-resistant tuberculosis (MDR/RR-TB) in Kazakhstan treated with one of 3 all-oral, 5-drug regimens. Individuals were followed microbiologically and clinically for up to 12 months post-treatment. Of 578 with favorable end-of-treatment outcomes, we observed only one incident case of recurrent TB (0.2%, 95% CI: 0.0–1.0%), suggesting excellent regimen durability under programmatic conditions.

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