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Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome

  • Author(s): Sapru, A
  • Calfee, CS
  • Liu, KD
  • Kangelaris, K
  • Hansen, H
  • Pawlikowska, L
  • Ware, LB
  • Alkhouli, MF
  • Abbot, J
  • Matthay, MA
  • et al.
Abstract

Objective: Thombomodulin (TM) is an activator of protein C and a biomarker for endothelial injury. We hypothesized that (1) elevated plasma levels would be associated with clinical outcomes and (2) polymorphisms in the TM gene would be associated with plasma levels.

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