Importance and challenges of environmental ligand binding and exchange: Introducing single molecule imaging as a model characterization technique
- Author(s): Saleh, NB
- Das, D
- Plazas-Tuttle, J
- Yang, D
- Del Bonis-O'Donnell, JT
- Landry, MP
- et al.
Published Web Locationhttps://doi.org/10.1016/j.impact.2017.03.005
© 2017 Highly surface active nano-scale materials, when released into the natural environment, tend to adsorb geo- and bio-macromolecules and end up presenting a modified interface to biological species. Capped nanocrystals and polymer/surfactant modified nanomaterials also are known to undergo ligand exchange when exposed to natural systems. Thus, nano-bio interactions will primarily be governed by the adsorbed or exchanged natural macromolecules. To-date there has been no established technique determining the kinetics of ligand exchange or characterizing the bound geo-biomacromolecular corona in an environmental setting. Single-molecule imaging utilizing near-infra red spectrometry, and single-molecule imaging of fluorophore-tagged polymeric ligands can enable detailed characterization of biopolymeric corona. This perspective aims to highlight the importance of ligand exchange, identify roles of surface ligands on nano-bio interaction, and present initial evidence of macromolecular characterization on nanotube surfaces using single-molecule techniques. This commentary also aims to outline the challenges facing nano-environmental health and safety community on assessing biological interaction with complex nano-scale heterostructures in a realistic environmental matrix.
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