Skip to main content
eScholarship
Open Access Publications from the University of California

Importance and challenges of environmental ligand binding and exchange: Introducing single molecule imaging as a model characterization technique

  • Author(s): Saleh, NB
  • Das, D
  • Plazas-Tuttle, J
  • Yang, D
  • Del Bonis-O'Donnell, JT
  • Landry, MP
  • et al.
Abstract

© 2017 Highly surface active nano-scale materials, when released into the natural environment, tend to adsorb geo- and bio-macromolecules and end up presenting a modified interface to biological species. Capped nanocrystals and polymer/surfactant modified nanomaterials also are known to undergo ligand exchange when exposed to natural systems. Thus, nano-bio interactions will primarily be governed by the adsorbed or exchanged natural macromolecules. To-date there has been no established technique determining the kinetics of ligand exchange or characterizing the bound geo-biomacromolecular corona in an environmental setting. Single-molecule imaging utilizing near-infra red spectrometry, and single-molecule imaging of fluorophore-tagged polymeric ligands can enable detailed characterization of biopolymeric corona. This perspective aims to highlight the importance of ligand exchange, identify roles of surface ligands on nano-bio interaction, and present initial evidence of macromolecular characterization on nanotube surfaces using single-molecule techniques. This commentary also aims to outline the challenges facing nano-environmental health and safety community on assessing biological interaction with complex nano-scale heterostructures in a realistic environmental matrix.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View