Arrowsmith, Cheryl H; Audia, James E; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E; Brown, Peter J; Bunnage, Mark E; Buser-Doepner, Carolyn; Campbell, Robert M; Carter, Adrian J; Cohen, Philip; Copeland, Robert A; Cravatt, Ben; Dahlin, Jayme L; Dhanak, Dashyant; Edwards, Aled M; Frederiksen, Mathias; Frye, Stephen V; Gray, Nathanael; Grimshaw, Charles E; Hepworth, David; Howe, Trevor; Huber, Kilian VM; Jin, Jian; Knapp, Stefan; Kotz, Joanne D; Kruger, Ryan G; Lowe, Derek; Mader, Mary M; Marsden, Brian; Mueller-Fahrnow, Anke; Müller, Susanne; O'Hagan, Ronan C; Overington, John P; Owen, Dafydd R; Rosenberg, Saul H; Ross, Ruth; Roth, Bryan; Schapira, Matthieu; Schreiber, Stuart L; Shoichet, Brian; Sundström, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris; Walters, Michael A; Willson, Timothy M; Workman, Paul; Young, Robert N; Zuercher, William J

doi:10.1038/nchembio.1867

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The promise and peril of chemical probes

2015

Arrowsmith, Cheryl H;
Audia, James E;
Austin, Christopher;
Baell, Jonathan;
Bennett, Jonathan;
Blagg, Julian;
Bountra, Chas;
Brennan, Paul E;
Brown, Peter J;
Bunnage, Mark E;
Buser-Doepner, Carolyn;
Campbell, Robert M;
Carter, Adrian J;
Cohen, Philip;
Copeland, Robert A;
Cravatt, Ben;
Dahlin, Jayme L;
Dhanak, Dashyant;
Edwards, Aled M;
Frederiksen, Mathias;
Frye, Stephen V;
Gray, Nathanael;
Grimshaw, Charles E;
Hepworth, David;
Howe, Trevor;
Huber, Kilian VM;
Jin, Jian;
Knapp, Stefan;
Kotz, Joanne D;
Kruger, Ryan G;
Lowe, Derek;
Mader, Mary M;
Marsden, Brian;
Mueller-Fahrnow, Anke;
Müller, Susanne;
O'Hagan, Ronan C;
Overington, John P;
Owen, Dafydd R;
Rosenberg, Saul H;
Ross, Ruth;
Roth, Bryan;
Schapira, Matthieu;
Schreiber, Stuart L;
Shoichet, Brian;
Sundström, Michael;
Superti-Furga, Giulio;
Taunton, Jack;
Toledo-Sherman, Leticia;
Walpole, Chris;
Walters, Michael A;
Willson, Timothy M;
Workman, Paul;
Young, Robert N;
Zuercher, William J
et al.

Published Web Location

https://doi.org/10.1038/nchembio.1867

Abstract

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

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The promise and peril of chemical probes

Published Web Location