- Main
Genetic association signal near NTN4 in Tourette syndrome
- Paschou, Peristera;
- Yu, Dongmei;
- Gerber, Gloria;
- Evans, Patrick;
- Tsetsos, Fotis;
- Davis, Lea K;
- Karagiannidis, Iordanis;
- Chaponis, Jonathan;
- Gamazon, Eric;
- Mueller‐Vahl, Kirsten;
- Stuhrmann, Manfred;
- Schloegelhofer, Monika;
- Stamenkovic, Mara;
- Hebebrand, Johannes;
- Noethen, Markus;
- Nagy, Peter;
- Barta, Csaba;
- Tarnok, Zsanett;
- Rizzo, Renata;
- Depienne, Christel;
- Worbe, Yulia;
- Hartmann, Andreas;
- Cath, Danielle C;
- Budman, Cathy L;
- Sandor, Paul;
- Barr, Cathy;
- Wolanczyk, Thomas;
- Singer, Harvey;
- Chou, I‐Ching;
- Grados, Marco;
- Posthuma, Danielle;
- Rouleau, Guy A;
- Aschauer, Harald;
- Freimer, Nelson B;
- Pauls, David L;
- Cox, Nancy J;
- Mathews, Carol A;
- Scharf, Jeremiah M
- et al.
Published Web Location
https://doi.org/10.1002/ana.24215Abstract
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10(-7) ). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-