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Enantioselective Coupling of Dienes and Phosphine Oxides

Published Web Location

https://doi.org/10.1021/jacs.8b11150
Abstract

We report a Pd-catalyzed intermolecular hydrophosphinylation of 1,3-dienes to afford chiral allylic phosphine oxides. Commodity dienes and air stable phosphine oxides couple to generate organophosphorus building blocks with high enantio- and regiocontrol. This method constitutes the first asymmetric hydrophosphinylation of dienes.

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