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Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia
- Tzoneva, Gannie;
- Dieck, Chelsea L;
- Oshima, Koichi;
- Ambesi-Impiombato, Alberto;
- Sánchez-Martín, Marta;
- Madubata, Chioma J;
- Khiabanian, Hossein;
- Yu, Jiangyan;
- Waanders, Esme;
- Iacobucci, Ilaria;
- Sulis, Maria Luisa;
- Kato, Motohiro;
- Koh, Katsuyoshi;
- Paganin, Maddalena;
- Basso, Giuseppe;
- Gastier-Foster, Julie M;
- Loh, Mignon L;
- Kirschner-Schwabe, Renate;
- Mullighan, Charles G;
- Rabadan, Raul;
- Ferrando, Adolfo A
Published Web Location
https://doi.org/10.1038/nature25186Abstract
Mutations in the nucleotidase-encoding gene NT5C2 drive chemotherapy resistance in relapsed acute lymphoid leukaemia but the mutations also lead to a loss-of-fitness phenotype and to collateral drug sensitivity, which could be exploited for therapy.
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