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Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients
- Neogi, Ujjwal;
- Shwetha, D RAO;
- BONTELL, Irene;
- VERHEYEN, Jens;
- Vasudev, R RAO;
- GORE, Sagar C;
- Neelesh, SONI;
- Anita, SHET;
- SCHÜLTER, Eugen;
- EKSTRAND, Maria L;
- WONDWOSSEN, Amogne;
- KAISER, Rolf;
- MADHUSUDHAN, Mallur S;
- PRASAD, Vinayaka R;
- SONNERBORG, Anders
Published Web Location
https://doi.org/10.1097/qad.0000000000000419Abstract
A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.
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