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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- Lee, Byoung Dae;
- Shin, Joo-Ho;
- VanKampen, Jackalina;
- Petrucelli, Leonard;
- West, Andrew B;
- Ko, Han Seok;
- Lee, Yun-Il;
- Maguire-Zeiss, Kathleen A;
- Bowers, William J;
- Federoff, Howard J;
- Dawson, Valina L;
- Dawson, Ted M
Published Web Location
https://doi.org/10.1038/nm.2199Abstract
Mutations in the kinase LRRK2 have been linked to Parkinson's disease. Now, Ted Dawson and his colleagues have identified inhibitors of LRRK2 that can reduce LRRK2-induced neurotoxicity in cell culture and in mice.
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