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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.

  • Author(s): Lee, Byoung Dae;
  • Shin, Joo-Ho;
  • VanKampen, Jackalina;
  • Petrucelli, Leonard;
  • West, Andrew B;
  • Ko, Han Seok;
  • Lee, Yun-Il;
  • Maguire-Zeiss, Kathleen A;
  • Bowers, William J;
  • Federoff, Howard J;
  • Dawson, Valina L;
  • Dawson, Ted M
  • et al.

Published Web Location

https://doi.org/10.1038/nm.2199
Abstract

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.

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