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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
- Franke, Barbara;
- Stein, Jason L;
- Ripke, Stephan;
- Anttila, Verneri;
- Hibar, Derrek P;
- van Hulzen, Kimm JE;
- Arias-Vasquez, Alejandro;
- Smoller, Jordan W;
- Nichols, Thomas E;
- Neale, Michael C;
- McIntosh, Andrew M;
- Lee, Phil;
- McMahon, Francis J;
- Meyer-Lindenberg, Andreas;
- Mattheisen, Manuel;
- Andreassen, Ole A;
- Gruber, Oliver;
- Sachdev, Perminder S;
- Roiz-Santiañez, Roberto;
- Saykin, Andrew J;
- Ehrlich, Stefan;
- Mather, Karen A;
- Turner, Jessica A;
- Schwarz, Emanuel;
- Thalamuthu, Anbupalam;
- Yao, Yin;
- Ho, Yvonne YW;
- Martin, Nicholas G;
- Wright, Margaret J;
- O'Donovan, Michael C;
- Thompson, Paul M;
- Neale, Benjamin M;
- Medland, Sarah E;
- Sullivan, Patrick F
Published Web Location
https://doi.org/10.1038/nn.4228Abstract
The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.
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