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Going retro: ancient viral origins of cognition.

  • Author(s): Campioni, Matthew R
  • Finkbeiner, Steven
  • et al.

In this issue of Neuron, Zhang et al. (2015) provide the first crystal structure of a domain Arc. These results confirm prior computational approaches that suggested Arc, a master regulator of vertebrate synaptic plasticity, was "domesticated" from Ty3/Gypsy retrotransposons.

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