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Going Retro: Ancient Viral Origins of Cognition
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https://doi.org/10.1016/j.neuron.2015.04.008Abstract
In this issue of Neuron, Zhang et al. (2015) provide the first crystal structure of a domain Arc. These results confirm prior computational approaches that suggested Arc, a master regulator of vertebrate synaptic plasticity, was "domesticated" from Ty3/Gypsy retrotransposons.
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