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Chemical informatics and target identification in a zebrafish phenotypic screen
- Laggner, Christian;
- Kokel, David;
- Setola, Vincent;
- Tolia, Alexandra;
- Lin, Henry;
- Irwin, John J;
- Keiser, Michael J;
- Cheung, Chung Yan J;
- Minor, Daniel L;
- Roth, Bryan L;
- Peterson, Randall T;
- Shoichet, Brian K
Published Web Location
https://doi.org/10.1038/nchembio.732Abstract
A cheminformatics approach helps identify proteins such as GPCRs, ion channels and kinases that are targeted by small molecules that give phenotypes in a zebrafish behavioral assay.
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