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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

et al.

Published Web Location

https://doi.org/10.1038/nbt.1645
Creative Commons 'BY' version 4.0 license
Abstract

Although general inhibitors of the ubiquitin-proteasome system have been reported, compounds targeting specific ubiquitylation enzymes should be beneficial in clinical applications and basic research. Aghajan et al. present an inhibitor of the yeast SCFMet30 E3 ligase that prevents the binding of the Met30 F-box protein to the core ligase complex.

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