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Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation
- Li, Peilin;
- Kaiser, Philipp;
- Lampiris, Harry W;
- Kim, Peggy;
- Yukl, Steven A;
- Havlir, Diane V;
- Greene, Warner C;
- Wong, Joseph K
Published Web Location
https://doi.org/10.1038/nm.4124Abstract
Li et al. show that the retinoic acid derivative acitretin activates HIV-1 transcription in latently infected T cells and induces RIG-I signaling, which leads to cell death and suggests an approach to reduce the HIV reservoir.
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