UC Research Initiatives supports multicampus research teams, partners UC and national laboratory scientists, and advances innovations that benefit California.
Memories link information about specific experiences to more general knowledge that is abstracted from and contextualizes those experiences. Hippocampal-cortical activity patterns representing features of past experience are reinstated during awake memory reactivation events, but whether representations of both specific and general features of experience are simultaneously reinstated remains unknown. We examined hippocampal and prefrontal cortical firing patterns during memory reactivation in rats performing a well-learned foraging task with multiple spatial paths. We found that specific hippocampal place representations are preferentially reactivated with the subset of prefrontal cortical task representations that generalize across different paths. Our results suggest that hippocampal-cortical networks maintain links between stored representations for specific and general features of experience, which could support abstraction and task guidance in mammals.
Related Research Centers & Groups
- Cancer Research Coordinating Committee (CRCC)
- UC Discovery Grant Program; a funding opportunity through UC Research Initiatives (UCRI)
- UC Lab Fees Research Program (LFRP); a funding opportunity through UC Research Initiatives (UCRI)
- Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI)
- Proof of Concept Commercialization Gap Grants (PoC); a funding opportunity through UC Research Initiatives (UCRI)
- California Breast Cancer Research Program
- California HIV/AIDS Research Program
- Tobacco-Related Disease Research Program
- Research Grants Program Office (RGPO)