UC Research Initiatives supports multicampus research teams, partners UC and national laboratory scientists, and advances innovations that benefit California.
Cell-to-cell communication networks have critical roles in coordinating diverse organismal processes, such as tissue development or immune cell response. However, compared with intracellular signal transduction networks, the function and engineering principles of cell-to-cell communication networks are far less understood. Major complications include: cells are themselves regulated by complex intracellular signaling networks; individual cells are heterogeneous; and output of any one cell can recursively become an additional input signal to other cells. Here, we make use of a framework that treats intracellular signal transduction networks as black boxes with characterized input-to-output response relationships. We study simple cell-to-cell communication circuit motifs and find conditions that generate bimodal responses in time, as well as mechanisms for independently controlling synchronization and delay of cell-population responses. We apply our modeling approach to explain otherwise puzzling data on cytokine secretion onset times in T cells. Our approach can be used to predict communication network structure using experimentally accessible input-to-output measurements and without detailed knowledge of intermediate steps.
Memories link information about specific experiences to more general knowledge that is abstracted from and contextualizes those experiences. Hippocampal-cortical activity patterns representing features of past experience are reinstated during awake memory reactivation events, but whether representations of both specific and general features of experience are simultaneously reinstated remains unknown. We examined hippocampal and prefrontal cortical firing patterns during memory reactivation in rats performing a well-learned foraging task with multiple spatial paths. We found that specific hippocampal place representations are preferentially reactivated with the subset of prefrontal cortical task representations that generalize across different paths. Our results suggest that hippocampal-cortical networks maintain links between stored representations for specific and general features of experience, which could support abstraction and task guidance in mammals.
Related Research Centers & Groups
- Cancer Research Coordinating Committee (CRCC)
- UC Discovery Grant Program; a funding opportunity through UC Research Initiatives (UCRI)
- UC Lab Fees Research Program (LFRP); a funding opportunity through UC Research Initiatives (UCRI)
- Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI)
- Proof of Concept Commercialization Gap Grants (PoC); a funding opportunity through UC Research Initiatives (UCRI)
- California Breast Cancer Research Program
- California HIV/AIDS Research Program
- Tobacco-Related Disease Research Program
- Research Grants Program Office (RGPO)