Climate-responsive building design holds immense potential for enhancing comfort, energy efficiency, and environmental sustainability. However, many social, cultural, and economic obstacles might prevent the wide adoption of designing climate-adapted buildings. One of these obstacles can be removed by enabling practitioners to easily access, visualize and analyze local climate data. The CBE Clima Tool (Clima) is a free and open-source web application that offers easy access to publicly available weather files and has been created for building energy simulation and design. It provides a series of interactive visualizations of the variables contained in the EnergyPlus Weather Files and several derived ones like the UTCI or the adaptive comfort indices. It is aimed at students, educators, and practitioners in the architecture and engineering fields. Since its inception, Clima’s user base has exhibited robust growth, attracting over 25,000 unique users annually from across 70 countries. Our tool is poised to revolutionize climate-adaptive building design, transcending geographical boundaries and fostering innovation in the architecture and engineering fields.

In this paper, we study the Orienteering Aisle-graphs Single-access Problem (OASP), a variant of the orienteering problem for a robot moving in a so-called single-access aisle-graph, i.e., a graph consisting of a set of rows that can be accessed from one side only. Aisle-graphs model, among others, vineyards or warehouses. Each aisle-graph vertex is associated with a reward that a robot obtains when visits the vertex itself. As the robot's energy is limited, only a subset of vertices can be visited with a fully charged battery. The objective is to maximize the total reward collected by the robot with a battery charge. We first propose an optimal algorithm that solves OASP in O(m^2 n^2) time for aisle-graphs with a single access consisting of m rows, each with n vertices. With the goal of designing faster solutions, we propose four greedy sub-optimal algorithms that run in at most O(mn (m+n)) time. For two of them, we guarantee an approximation ratio of 1/2(1-1/e), where e is the base of the natural logarithm, on the total reward by exploiting the well-known submodularity property. Experimentally, we show that these algorithms collect more than 80% of the optimal reward.

In this paper, we consider the Constant-cost Orienteering Problem (COP) where a robot, constrained by a limited travel budget, aims at selecting a path with the largest reward in an aisle-graph. The aisle-graph consists of a set of loosely connected rows where the robot can change lane only at either end, but not in the middle. Even when considering this special type of graphs, the orienteering problem is known to be NP-hard. We optimally solve in polynomial time two special cases, COP-FR where the robot can only traverse full rows, and COP-SC where the robot can access the rows only from one side. To solve the general COP, we then apply our special case algorithms as well as a new heuristic that suitably combines them. Despite its light computational complexity and being confined into a very limited class of paths, the optimal solutions for COP-FR turn out to be competitive even for COP in both real and synthetic scenarios. Furthermore, our new heuristic for the general case outperforms state-of-art algorithms, especially for input with highly unbalanced rewards.

Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohns disease (CD) and ulcerative colitis (UC) predisposes to IMC. In this study, we first develop a polygenic risk scores for CD (PRSCD) and UC (PRSUC) in cancer-free individuals and then test these PRSs on IMC in a cohort of 1316 patients with ICI-treated non-small cell lung cancer and perform a replication in 873 ICI-treated pan-cancer patients. In a meta-analysis, the PRSUC predicts all-grade IMC (ORmeta=1.35 per standard deviation [SD], 95% CI = 1.12-1.64, P = 2×10-03) and severe IMC (ORmeta=1.49 per SD, 95% CI = 1.18-1.88, P = 9×10-04). PRSCD is not associated with IMC. Furthermore, PRSUC predicts severe IMC among patients treated with combination ICIs (ORmeta=2.20 per SD, 95% CI = 1.07-4.53, P = 0.03). Overall, PRSUC can identify patients receiving ICI at risk of developing IMC and may be useful to monitor patients and improve patient outcomes.

South American (SA) societies are highly vulnerable to droughts and pluvials, but lack of long-term climate observations severely limits our understanding of the global processes driving climatic variability in the region. The number and quality of SA climate-sensitive tree ring chronologies have significantly increased in recent decades, now providing a robust network of 286 records for characterizing hydroclimate variability since 1400 CE. We combine this network with a self-calibrated Palmer Drought Severity Index (scPDSI) dataset to derive the South American Drought Atlas (SADA) over the continent south of 12°S. The gridded annual reconstruction of austral summer scPDSI is the most spatially complete estimate of SA hydroclimate to date, and well matches past historical dry/wet events. Relating the SADA to the Australia-New Zealand Drought Atlas, sea surface temperatures and atmospheric pressure fields, we determine that the El Niño-Southern Oscillation (ENSO) and the Southern Annular Mode (SAM) are strongly associated with spatially extended droughts and pluvials over the SADA domain during the past several centuries. SADA also exhibits more extended severe droughts and extreme pluvials since the mid-20th century. Extensive droughts are consistent with the observed 20th-century trend toward positive SAM anomalies concomitant with the weakening of midlatitude Westerlies, while low-level moisture transport intensified by global warming has favored extreme rainfall across the subtropics. The SADA thus provides a long-term context for observed hydroclimatic changes and for 21st-century Intergovernmental Panel on Climate Change (IPCC) projections that suggest SA will experience more frequent/severe droughts and rainfall events as a consequence of increasing greenhouse gas emissions.

In order to reduce recirculating power fraction to acceptable levels, the spherical torus concept relies on the simultaneous achievement of high toroidal β and high bootstrap fraction in steady state. In the last year, as a result of plasma control system improvements, the achievable plasma elongation on NSTX has been raised from κ ∼ 2.1 to κ ∼ 2.6 - approximately a 25% increase. This increase in elongation has led to a substantial increase in the toroidal β for long pulse discharges. The increase in β is associated with an increase in plasma current at nearly fixed poloidal β, which enables higher βt with nearly constant bootstrap fraction. As a result, for the first time in a spherical torus, a discharge with a plasma current of 1 MA has been sustained for 1 s (0.8 s current flat-top). Data are presented from NSTX correlating the increase in performance with increased plasma shaping capability. In addition to improved shaping, H-modes induced during the current ramp phase of the plasma discharge have been used to reduce flux consumption and to delay the onset of MHD instabilities. Based on these results, a modelled integrated scenario, which has 100% non-inductive current drive with very high toroidal β, will also be discussed. The NSTX poloidal field coils are currently being modified to produce the plasma shape which is required for this scenario, which requires high triangularity (δ ∼ 0.8) at elevated elongation (κ ∼ 2.5). The other main requirement of steady state on NSTX is the ability to drive a fraction of the total plasma current with RF waves. The results of high harmonic fast wave heating and current drive studies as well as electron Bernstein wave emission studies will be presented. © 2006 IAEA, Vienna.

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Differences in the behaviour of matter and antimatter have been observed in K and B meson decays, but not yet in any baryon decay. Such differences are associated with the non-invariance of fundamental interactions under the combined charge-conjugation and parity transformations, known as CP violation. Here, using data from the LHCb experiment at the Large Hadron Collider, we search for CP-violating asymmetries in the decay angle distributions of Λb0 baryons decaying to pπ- π+ π- and pπ-K+K- final states. These four-body hadronic decays are a promising place to search for sources of CP violation both within and beyond the standard model of particle physics. We find evidence for CP violation in Λb0 to pπ- π+ π- decays with a statistical significance corresponding to 3.3 standard deviations including systematic uncertainties. This represents the first evidence for CP violation in the baryon sector.

The National Spherical Torus Experiment (NSTX) has explored the effects of shaping on plasma performance as determined by many diverse topics including the stability of global magnetohydrodynamic (MHD) modes (e.g., ideal external kinks and resistive wall modes), edge localized modes (ELMs), bootstrap current drive, divertor flux expansion, and heat transport. Improved shaping capability has been crucial to achieving Βt ∼40%. Precise plasma shape control has been achieved on NSTX using real-time equilibrium reconstruction. NSTX has simultaneously achieved elongation κ∼2.8 and triangularity δ∼0.8. Ideal MHD theory predicts increased stability at high values of shaping factor S≡ q95 Ip (a Bt), which has been observed at large values of the S∼37 [MA (m·T)] on NSTX. The behavior of ELMs is observed to depend on plasma shape. A description of the ELM regimes attained as shape is varied will be presented. Increased shaping is predicted to increase the bootstrap fraction at fixed Ip. The achievement of strong shaping has enabled operation with 1 s pulses with Ip =1 MA, and for 1.6 s for Ip =700 kA. Analysis of the noninductive current fraction as well as empirical analysis of the achievable plasma pulse length as elongation is varied will be presented. Data are presented showing a reduction in peak divertor heat load due to increasing in flux expansion. © 2006 American Institute of Physics.