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eScholarship
Open Access Publications from the University of California

Scholarly Works (22 results)

  • Article
  • Peer Reviewed
Lawrence Berkeley National Laboratory (2009)
    Cover page: Eu(III) Complexes of Octadentate 1-Hydroxy-2-pyridinones: Stability and Improved Photophysical Performance
    • Article
    Lawrence Berkeley National Laboratory (2009)
      Cover page: Use of Yb(III) Centered Near Infra-Red (NIR) Luminescence to Determine the Hydration State of a 3,2-HOPO based MRI-Contrast Agent
      • Article
      LBL Publications (2008)
        Cover page: 3,2-HOPO Complexes of Near-Infra-Red (NIR) Emitting Lanthanides: Sensitization of Ho(III) and Pr(III) in Aqueous Solution
        • Article
        • Peer Reviewed
        LBL Publications (2011)
          Cover page: Me-3,2-HOPO Complexes of Near Infra-Red (NIR) Emitting Lanthanides: Efficient Sensitization of Yb(III) and Nd(III) in Aqueous Solution
          • Article
          • Peer Reviewed
          Lawrence Berkeley National Laboratory (2007)
            Cover page: An Octadentate Luminescent Eu(III) 1,2-HOPO Chelate with Potent Aqueous Stability
            • Article
            • Peer Reviewed
            UC San Francisco Previously Published Works (2004)

            We have previously described a transgenic mouse model of epidermal neoplasia wherein expression of a switchable form of c-Myc, MycER(TAM), is targeted to the postmitotic suprabasal keratinocytes of murine epidermis via the involucrin promoter. Sustained activation of c-MycER(TAM) results in a progressive neoplastic phenotype characterized by aberrant ectopic proliferation and delayed differentiation of suprabasal keratinocytes, culminating in papillomatosis. Transcription of the Id2 gene is regulated by Myc family proteins. Moreover, 142 is implicated as a pivotal determinant of cell fate in multiple lineages and has a demonstrated role in mediating Myc-dependent cell proliferation in vitro through its interaction with retinoblastoma protein. Using Id2 nullizygous mice, we assessed in vivo the requirement for 142 in mediating Myc-induced papilloma formation in skin. We show that absence of Id2 has no discernible impact on any measurable attribute of Myc function or on the timing or extent of eventual tumor formation. Thus, our data argue against any essential role for Id2 in mediating Myc action in vivo.

              Cover page: Id2 is dispensable for Myc-induced epidermal neoplasia
              • Article
              • Peer Reviewed
              UC Berkeley Previously Published Works (2015)
              The synthesis of a series of octadentate ligands containing the 1-hydroxypyridin-2-one (1,2-HOPO) group in complex with europium(III) is reported. Within this series, the central bridge connecting two diethylenetriamine units linked to two 1,2-HOPO chromophores at the extremities (5-LIN-1,2-HOPO) is varied from a short ethylene chain (H(2,2)-1,2-HOPO) to a long pentaethylene oxide chain (H(17O5,2)-1,2-HOPO). The thermodynamic stability of the europium complexes has been studied and reveals these complexes may be effective for biological measurements. Extension of the central bridge results in exclusion of the inner-sphere water molecule observed for [Eu(H(2,2)-1,2-HOPO)](-) going from a nonacoordinated to an octacoordinated Eu(III) ion. With the longer chain length ligands, the complexes display increased luminescence properties in aqueous medium with an optimum of 20% luminescence quantum yield for the [Eu(H(17O5,2)-1,2-HOPO)](-) complex. The luminescence properties for [Eu(H(14O4,2)-1,2-HOPO)](-) and [Eu(H(17O5,2)-1,2-HOPO)](-) are better than that of the model bis-tetradentate [Eu(5LIN(Me)-1,2-HOPO)2](-) complex, suggesting a different geometry around the metal center despite the geometric freedom allowed by the longer central chain in the H(mOn,2) scaffold. These differences are also evidenced by examining the luminescence spectra at room temperature and at 77 K and by calculating the luminescence kinetic parameters of the europium complexes.
                Cover page: Optimization of the Sensitization Process and Stability of Octadentate Eu(III) 1,2-HOPO Complexes
                • Article
                • Peer Reviewed
                Lawrence Berkeley National Laboratory (2007)
                  Cover page: Enantiopure, Octadentate Ligands as Sensitizers for Europium and Terbium Circularly Polarized Luminescence in Aqueous Solution
                  • Article
                  • Peer Reviewed
                  UC San Francisco Previously Published Works (2013)
                  SALL2- a member of the Spalt gene family- is a poorly characterized transcription factor found deregulated in various cancers, which suggests it plays a role in the disease. We previously identified SALL2 as a novel interacting protein of neurotrophin rece
                    • Article
                    • Peer Reviewed
                    Lawrence Berkeley National Laboratory (2008)
                      Cover page: 1,2-Hydroxypyridonates as Contrast Agents for Magnetic Resonance Imaging: TREN-1,2-HOPO
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