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Open Access Publications from the University of California

Scholarly Works (6 results)

  • Multimedia
  • Peer Reviewed
CMPM 80K (2020)
This game is about a jungle adventure and also shows a love store in the game. There are multiple lines in the game. Some choices will impact the game but some choices will not. I also try to let the player make a hard choice for some choices. There is one bad and one good end in the game.
  • 1 supplemental file
Creative Commons 'BY' version 4.0 license
  • Thesis
  • Peer Reviewed
UC Irvine Electronic Theses and Dissertations (2018)

Even about 70% of our planet is covered by water, lack of access to clean water is still a pervasive problem disturbing people all over the world. Water problems are deemed to be worse in future, given the rapidly growing population. To solve these problems calls out for a tremendous amount of research to be conducted to develop new methods/technologies of economically purifying water and harvesting water, as well as reducing associated negative impact on the environment.

In this study, we investigated water condensation at a cooled surface and the impacts of the surface property and temperature. A device was designed and developed to collect the water condensation rate in a controlled environment. The Alumina surface was used as a substrate to collect water condensation under various cooling levels of the surface. Experiment data show that the water condensation rate rapidly decreases as the difference between the surface and environmental temperature goes down. Graphene is 2D carbon materials and It is a sheet of single-atom-layer thickness which consist of sp2-hydridized carbon atoms arranged in a hexagonal honeycomb structure. It offers many super properties including high electrical and thermal conductivities, great mechanical properties. To investigate its presence’s impacts on water condensation rate, the Al surface randomly dispersed with graphenes was tested under the same condition to study the impact of the graphene presence on the water condensation rate. No obvious influence was identified. The study is important to investigate the surface’s enhancement of phase change and water harvest from ambient air.

    Cover page: Water Harvesting In Ambient Air
    • Article
    • Peer Reviewed
    UC San Diego Previously Published Works (2017)

    Background

    Treatment of mild-moderate Alzheimer's disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores.

    Methods

    For this retrospective study, we examined banked CSF and plasma samples from a subset of AD subjects with CSF Aβ42 <600 ng/ml (biomarker-confirmed AD) at baseline (N = 19 resveratrol-treated and N = 19 placebo-treated). We utilized multiplex Xmap technology to measure markers of neurodegenerative disease and metalloproteinases (MMPs) in parallel in CSF and plasma samples.

    Results

    Compared to the placebo-treated group, at 52 weeks, resveratrol markedly reduced CSF MMP9 and increased macrophage-derived chemokine (MDC), interleukin (IL)-4, and fibroblast growth factor (FGF)-2. Compared to baseline, resveratrol increased plasma MMP10 and decreased IL-12P40, IL12P70, and RANTES. In this subset analysis, resveratrol treatment attenuated declines in mini-mental status examination (MMSE) scores, change in ADL (ADCS-ADL) scores, and CSF Aβ42 levels during the 52-week trial, but did not alter tau levels.

    Conclusions

    Collectively, these data suggest that resveratrol decreases CSF MMP9, modulates neuro-inflammation, and induces adaptive immunity. SIRT1 activation may be a viable target for treatment or prevention of neurodegenerative disorders.

    Trial registration

    ClinicalTrials.gov NCT01504854.
      Cover page: Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease
      • Article
      • Peer Reviewed
      UC Irvine Previously Published Works (2022)
      In this paper, a new pyrroloquinoline-derivative-based fluorescent probe, PQP-1, was prepared for the selective detection of Lys in living cells and natural mineral water for drinking. PQP-1 exhibited high selectivity, low limit of detection, and a wide pH range. PQP-1 could be successfully applied for imaging Lys in living cells and in natural mineral water for drinking. We expect that PQP-1 will expand the detection reaction mechanism and the practical biological applications of Lys.
        Cover page: A New Pyrroloquinoline-Derivative-Based Fluorescent Probe for the Selective Detection and Cell Imaging of LysineCreative Commons 'BY' version 4.0 license
        • Article
        • Peer Reviewed
        UC Riverside Previously Published Works (2023)
        The DELLA genes, also known as 'Green Revolution' genes, encode conserved master growth regulators that control plant development in response to internal and environmental cues. Functioning as nuclear-localized transcription regulators, DELLAs modulate expression of target genes via direct protein-protein interaction of their carboxy-terminal GRAS domain with hundreds of transcription factors (TFs) and epigenetic regulators. However, the molecular mechanism of DELLA-mediated transcription reprogramming remains unclear. Here by characterizing new missense alleles of an Arabidopsis DELLA, repressor of ga1-3 (RGA), and co-immunoprecipitation assays, we show that RGA binds histone H2A via the PFYRE subdomain within its GRAS domain to form a TF-RGA-H2A complex at the target chromatin. Chromatin immunoprecipitation followed by sequencing analysis further shows that this activity is essential for RGA association with its target chromatin globally. Our results indicate that, although DELLAs are recruited to target promoters by binding to TFs via the LHR1 subdomain, DELLA-H2A interaction via the PFYRE subdomain is necessary to stabilize the TF-DELLA-H2A complex at the target chromatin. This study provides insights into the two distinct key modular functions in DELLA for its genome-wide transcription regulation in plants.
          Cover page: The master growth regulator DELLA binding to histone H2A is essential for DELLA-mediated global transcription regulationCreative Commons 'BY' version 4.0 license
          • Article
          • Peer Reviewed
          UC Irvine Previously Published Works (2022)
          Tumor metastasis is a leading cause of breast cancer-related death. Taxane-loaded polymeric formulations, such as Genexol PM and Nanoxel M using poly(ethylene glycol)-poly(d,l-lactide) (PEG-PLA) micelles as drug carriers, have been approved for the treatment of metastatic breast cancer. Unfortunately, the physical instability of PEG-PLA micelles, leading to poor drug loading, premature drug leakage, and consequently limited drug delivery to tumors, largely hinders their therapeutic outcome. Inspired by the enantiomeric nature of PLA, this work developed stereocomplex PEG-PLA micelles through stereoselective interactions of enantiomeric PLA, which are further incorporated with a hypoxia-responsive moiety used as a hypoxia-cleavable linker of PEG and PLA, to maximize therapeutic outcomes. The results showed that the obtained micelles had high structural stability, showing improved drug loading for effective drug delivery to tumors as well as other tissues. Especially, they were capable of sensitively responding to the hypoxic tumor environment for drug release, reversing hypoxia-induced drug resistance and hypoxia-promoted cell migration for enhanced bioavailability under hypoxia. In vivo results further showed that the micelles, especially at a high dose, inhibited the growth of the primary tumor and improved tumor pathological conditions, consequently remarkably inhibiting its metastasis to the lungs and liver, while not causing any systemic toxicity. Hypoxia-responsive stereocomplex micelles thus emerge as a reliable drug delivery system to treat breast cancer metastasis.
            Cover page: Hypoxia-Responsive Stereocomplex Polymeric Micelles with Improved Drug Loading Inhibit Breast Cancer Metastasis in an Orthotopic Murine ModelCreative Commons 'BY' version 4.0 license
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