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High nasal burden of methicillin-resistant Staphylococcus aureus increases risk of invasive disease.

  • Author(s): Datta, Rupak;
  • Shah, Atia;
  • Huang, Susan S;
  • Cui, Eric;
  • Nguyen, Vinh;
  • Welbourne, Susan J;
  • Quan, Kathleen A;
  • Thrupp, Lauri
  • et al.
Abstract

In a retrospective cohort study of 1,140 patients harboring methicillin-resistant Staphylococcus aureus, the nasal burden was low in 31%, category 1+ to 2+ in 54%, and category 3+ to 4+ in 15%. There was a significant trend in infection risk with increasing nasal burden (P = 0.007). In multivariate models, high nasal burden remained significantly associated with invasive infection.

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