High nasal burden of methicillin-resistant Staphylococcus aureus increases risk of invasive disease.
Published Web Locationhttps://doi.org/10.1128/jcm.01606-13
In a retrospective cohort study of 1,140 patients harboring methicillin-resistant Staphylococcus aureus, the nasal burden was low in 31%, category 1+ to 2+ in 54%, and category 3+ to 4+ in 15%. There was a significant trend in infection risk with increasing nasal burden (P = 0.007). In multivariate models, high nasal burden remained significantly associated with invasive infection.